Objective
In the last decade, new technologies have emerged to study protein-protein and protein-nucleic acid interactions under near-physiological conditions at large scale. In contrast, development of similar performing technologies for screening and discovery of in vivo metabolite/protein interactions has received little attention. Nonetheless, metabolites comprise a large and important fraction of the cellular molecules. Many can bind proteins as substrates, products, cofactors, and ligands, and thereby constitute metabolic networks or regulate a myriad of environmental and developmental responses, often at very low concentrations. Here, we will establish a performing method for the discovery of novel in vivo protein-metabolite interactions in the model plant Arabidopsis thaliana by adapting an available high throughput protein affinity purification/mass spectrometry platform used for detecting protein-protein interactions. Receptor proteins involved in jasmonate signalling will be used as the model systems to discover new metabolites that interact in vivo with proteins. Ultimately, the role of the identified metabolites and the relevance of their molecular interactions for the jasmonate signalling cascades that steer growth and metabolism will be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.