Objective
The cellular plasma membrane is composed mainly of lipids and proteins. The bioactivity of the plasma membrane (such as the activation of receptors) is not only triggered and influenced by protein-protein or lipid-protein interactions, but also by bulk properties of the membrane such as the order or packing of lipids. In this project, I aim to understand how lipid packing influences membrane related processes in immunology such as T-cell signaling or antigen presentation. It is believed that lipid packing may have an important role in membrane-related immunological processes by concentrating various key molecules in a specific part of the membrane, thus constituting a catalytic platform to initiate signaling. However, numerous important questions remain, some of which I would like to pursue during my postdoctoral period using novel tools on model membranes and living cells: Is there any heterogeneity in lipid packing in the plasma membrane of T-cells or antigen-presenting (primary) cells? How does a variation in lipid packing effect the compartmentalization of key-proteins involved in T-cell signaling and antigen presentation, and how does this variation and compartmentalization effect functionality? Following that, I would like to develop an in-vitro lipid-protein vesicle system to model important characteristics of this aspect of immunology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.