Objective
Asthma is an active area of respiratory research due to its impact on morbidity and mortality worldwide. The limited treatment options available to severe asthmatics represent a great challenge. Severe asthma is associated with neutrophilia but the role of neutrophils in this pathology remains poorly defined. A greater understanding of the role of neutrophil proteases will lead to the development of novel avenues for therapy.
This project provides a unique opportunity to define the role of neutrophils and their proteases in directing the cellular inflammation and pulmonary remodelling in a clinically relevant model of allergen induced airway disease. I will combine established murine models of house dust mite-induced asthma and expertise in neutrophil/protease biology to address key questions on this unmet need for the first time. I will define the contribution of neutrophils to the development of pulmonary inflammation and structural changes due to HDM, to what extent are neutrophils responsible for the pulmonary protease imbalance in the allergic lung and the roles of their proteases and matrikines, and I will address how do neutrophils alter the homeostatic regulatory pathways within the lung. I will enhance my expertise gaining a comprehensive understanding and hands-on experience of in vivo models of asthma and complex downstream analysis by flow cytometry, mass spectrometry and microarrays, benefitting from the internationally renowned experience of the host groups. My current expertise in respiratory diseases coupled with a capacity to readily assimilate new knowledge and skill sets provides me with the ideal platform to address and successfully execute the project.
This project will provide key tools for understanding the role of neutrophils in asthma, contributing to future studies that may identify key therapeutic targets for drug design in order to alleviate this disease worldwide, enhancing the EU’s position at the forefront of advances in this field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- medical and health sciences basic medicine pathology
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.