Objective
MembraneLipidTherapy proposal is a translational research project introducing an innovative therapeutic approach for fighting cancer disease that takes advantage of inter-sectoral industry-academia strengths and international cooperation.
Membrane Lipid Therapy relies on the specific lipid composition from the cell membrane in tumour cells as a strong element controlling tumour growth surpassing oncogene activation or tumour suppressor inactivation. Particularly the ratio of membrane lipids phosphatidilethanol-amine:sphingomyelin (PE:SM) is ten times higher in tumour cells when compared to wild type cells.
This finding allowed the host group to rationally design the new antitumor drug Minerval®, first known activator of sphingomyelin synthase (SGMS-1 and -2), the protein responsible for maintaining the balance between PE and SM in the membrane by using the former as substrate to synthesize the latter. Minerval®, developed by Lipopharma Therapeutics (spin-off company from University of the Balearic Islands), is currently in multicenter phase II clinical trial for treatment of gliomas and other solid tumours.
All of the above supports Minerval® relevance as new antitumor therapy; however, further characterization of the molecular mechanism underlying Minerval® action is needed for approval and distribution of Minerval in the next future. The aim of this project is to gain more insight in this issue.
Laboratory animal models combined with histology techniques, microscopy and imaging and molecular biology techniques together with analytical chemistry, molecule structure techniques and computer-aided drug design will be used to determine:
1. The molecular mechanism underlying the altered PE:SM ratio in tumour cells.
2. The domains in SGMS interacting with Minerval.
3. The molecular pathway implicated in SGMS regulation.
Last but not least, the generated knowledge will be used for the ultimate aim of designing new drugs targeting SGMS1 and SGMS2 for antitumor therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences analytical chemistry
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
07122 Palma De Mallorca
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.