Cel "MICartRegen is a multidisciplinary and highly innovative project aimed at designing and producing a novel multi-biofunctional, cell-free prototype orthopaedic implant able to induce, stimulate and sustain self-repair of injured cartilage tissue. This implant would be used to promote the in-situ regeneration of functional articular cartilage in lesions caused by trauma and early stage osteoarthritis. The proposed implant is novel, cell-free and differs in its mode of action from other devices on the market.In brief, the implant will contain a) Bioactive molecules to recruit and retain ""repair cells"" (mesenchymal stem cells) from the joint fluid or released by the orthopaedic surgeon by subchondral drilling; b) Bioactive factors to promote maturation of the recruited stem cells into cartilage cells (chondrocytes) to produce the required extracellular matrix components. The technologies used to fabricate the prototype implant are adaptable, therefore custom fabrication of sophisticated bioactive scaffolds for different biomaterials containing various bioactive factors would be possibleThe success of the project relies on the strong background in biomaterials science, largely in bio-functionalisation and genetic activation of materials, of the candidate, combined with complimentary skills and infrastructure of the host.MICartRegen will also give the candidate an opportunity to be trained in new methods on biological evolution of biomaterials, and transferable skills that will greatly boost her career. Furthermore, it will help her to become an independent and experienced researcher able to plan and manage her research, disseminate the results, up to industrial exploitation, through participation in courses and cooperation with experienced scientists." Dziedzina nauki medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineorthopaedicsengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator THE UNIVERSITY OF SHEFFIELD Wkład UE € 231 283,20 Adres FIRTH COURT WESTERN BANK S10 2TN Sheffield Zjednoczone Królestwo Zobacz na mapie Region Yorkshire and the Humber South Yorkshire Sheffield Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Andrew King (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
