Objective
One of the modern challenges of cell biologists is to fully understand the mechanisms underlying cell lineage that takes place during the development of multicellular organisms. This is of importance in context of adult stem cells that alternate between quiescent and proliferation states, then dividing asymmetrically to give rise to a self-renewal stem cell plus a differentiating cell. The asymmetric determinants conferring self-renewal properties are still unknown. Of interest, in yeast Saccharomyces cerevisiae the spores that are the meiotic products of the sporulation of diploid cells display a lineage-specific asymmetric division of kinetochore components. Because the kinetochores are directly responsible for segregating chromatids during mitosis, a tempting hypothesis is that the asymmetric segregation is involved in nonrandom segregation of sister chromatids to daughter cells immediately after meiosis. The phenotype described provides an avenue through which such a nonrandom pattern of chromatid segregation could be achieved and concurrently provides a new yeast model for the cellular asymmetry to characterize determinants of the asymmetry. The power of the budding yeast S. cerevisiae in combination with various approaches, including proteomics, genetics and cell biology, will be utilized i) to identify the key properties of cell cycle control and DNA replication in the first cell cycle after exit from quiescence, ii) to characterize the full complement of epigenetic marks/proteins that segregate asymmetrically after this first division, iii) to unravel the mechanisms underlying their asymmetric distribution to daughter cells and iv) to determine which are the cell fate determinants responsible for the establishment of a cell lineage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics heredity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.