Objective
Veterinary pharmaceuticals are potent environmental contaminants. Special attention has been paid to antibiotics because of their potential health risk. Research has been undertaken to understand their environmental fate and toxicity. However one very important phenomenon has been overlooked and it is that more than half of the drugs currently in use are chiral compounds. Chiral compounds can exist in the form of enantiomers, which have similar physicochemical properties but differ in their biological properties and, therefore, in their potency, toxicity and biodegradation. Because of the most of studies on chiral pharmaceuticals do not explicitly account for individual stereoisomers, they implicitly and incorrectly assumes that enantiomers have identical environmental behavior. Furthermore, there is also a lack of information concerning enantioselective toxicity of chiral pharmaceuticals in the environment. This might lead to a significant under- or overestimation of their toxicity, as well as, an incorrect environmental risk assessment.Trace analysis of pharmaceuticals in environmental samples is always challenging due to the complexity and diversity of sample matrices, and until today only few chiral analytical methods for environmental trace-level determinations have been developed being the most of them focus on a few pharmaceuticals, and none of them in a group of several veterinary pharmaceuticals of environmental relevance.
The proposal concerns the development and validation of a method for enantiomeric analysis of a group of chiral veterinary medicines of environmental relevance in environmental matrices using microextraction techniques and determination by liquid chromatography coupled with tandem mass spectrometry, the study of their environmental fate and their toxicity effects towards different organisms and the evaluation of the environmental risk posed by these compounds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- agricultural sciences veterinary sciences
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BA2 7AY Bath
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.