Objective
An outstanding question in Neuroscience is to understand how the brain integrates sensory and non-sensory information. Strikingly, this integration takes place even in the primary sensory cortices, where sensory processing is strongly modulated by non-sensory context. For example, in primary visual cortex (V1), responses depend not only on visual stimulation, but also on locomotion (Niell and Stryker 2010, Neuron 65). Specifically, locomotion controls the spatial integration of V1 neurons, reducing the suppression they receive from the surround of their receptive fields (Ayaz, et al. 2013, Curr Biol 23). I will investigate the neural mechanisms underlying this phenomenon. My working hypothesis is that different classes of cortical interneurons contribute in a very specific manner to surround suppression and to modulation by locomotion. I will test this through a combination of experiment and computational modeling. First, I will measure how the different neural classes are activated for different stimulus sizes during rest and running. I will use 2-photon imaging to record the calcium activity of neurons in the superficial layers of V1 in mouse lines where I can simultaneously identify the classes of the interneurons thanks to a red fluorescent protein. Second, I will summarize these measures with a neural network model in which the different classes of neurons will be described by different variables, to match the experimental data. The circuits and computations uncovered by this project are likely to generalize to other areas of the cerebral cortex, and therefore to constitute fundamental organizational principles for cortical integration of internal and external inputs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.