Objective
Human parechovirus 3 (HPeV3) belongs to the genus Parechovirus within the large and growing family of Picornaviridae. Currently, the Picornaviridae family contains 37 species grouped into 17 genera. All picornaviruses are small icosahedrally-symmetric non-enveloped viruses that possess single-stranded, positive-sense RNA genomes. Picornaviruses, including parechoviruses, contain significant human pathogens that can cause a wide range of disease symptoms. Parechoviruses mainly cause asymptomatic or mild infections primarily in small children. Recently, however, there have been many case reports describing parechovirus association with encephalitis, meningitis and neonatal sepsis. Due to the relatively simple protein components of parechovirus (just three major capsid proteins which are highly variable, and some very conserved non-structural proteins), the majority of the variation in disease is associated with the variation in the capsid proteins.
The entry pathway of parechoviruses is poorly understood. In general the understanding on picornavirus entry is built on the evidence obtained from a few model viruses. The HPeV1 life cycle starts via binding of the virus to integrin receptor(s) on the surface of the host cell; then follows virus internalization via clathrin-mediated endocytosis and transport of the virus in endosomal vesicles to the site of replication in the cell interior. HPeV1 binds to two integrins, αVβ3 and αVβ6, via its RGD motif located in VP1 on the capsid. HPeV3 does not possess a RGD motif thus further studies are needed to elucidate the HPeV3 entry pathway. This project aims to unravel structural and biological properties of HPeV3 to facilitate a progress in parechovirus diagnostic and treatment. Such highly innovative methods as cryo EM, CEMOVIS and 3D organ culture will be applied.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 HELSINGIN YLIOPISTO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.