Objective
Highly sensitive biological detection opens new opportunities for biomolecular sensing. Label-free detection with high-Q microcavities is highly advantageous to perform label-free sensing due to its high sensitivity. We propose to develop a platform for multiplex label-free sensing with microring resonators. Close to the ring, we fabricate nanoscale pores (nanopores) for positioning control. This allows control of biomolecules position by electrophoretic force, without the need of surface immobilisation. Structures are designed to allow for multiplex sensing. The sensitivity is optimised thanks to the microrings properties as well as positioning and properties of the nanopores. Microring resonators are fabricated on a silicon-on-insulator substrate, using standard CMOS processing, allowing for cheap mass fabrication and integration with multiple sensing spots for real-time sensing in a lab on chip format. SOI offers a high refractive index contrast suitable for the fabrication of nanophotonic circuits including micron- and submicron sized optical cavities of very high quality. Solid-state nanopores are fabricated on Si3N4 membranes, using focused ion beam process. We also implement fluidic integration and optical set-up for multiplex measurement of resonant profiles. A tunable light source beam of wavelength l=1.3 micron is coupled in an input waveguide. It is further multiplexed to sense several rings in parallel. Translocation events through the nanopores induce a change of refractive index and therefore of guiding properties which may be measured through resonant response. Our technique allows performing biological sensing without the need of biomolecules immobilisation on a chip substrate. Biological tests are first carried out with DNA ladders for fragment sizing. We will then study potential of our platform for fingerprinting of proteins. It will open new opportunities to diagnosis applications as well as to study analytical measurements in complex systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.