Objective
Bacillus subtilis is a model organism for basic and applied research that has been intensively studied for more than two decades in the course of EU-funded research consortia and – with the FP7-project BaSynthec – has recently entered the age of Synthetic Biology (SynBio). This emerging interdisciplinary research area has a huge potential for biotechnological applications and is a major focus of upcoming EU-funded research initiatives, as reflected by the first transnational ERASynBio call this year and the focus of the EU-program Horizon 2020 on innovation and biotechnology. Based on the comprehensive knowledge of B. subtilis biology, its potential as an important chassis for future SynBio applications is unquestioned. But the lack of standardized tools for designing and implementing in vivo expression programs for metabolic engineering currently limits its use. It is the aim of this project to contribute to such a genetic toolbox by exploiting the enormous potential of Extracytoplasmic Function σ factors (ECFs). These transcriptional regulators provide a huge reservoir for developing SynBio switches. But since their diversity, specificity and ubiquitous distribution has only recently been discovered by the host group, ECFs have so far not been used for SynBio purposes. Using the comprehensive knowledge of the host group on B. subtilis genetics, ECF biology, and SynBio rationales, this project aims at developing innovative orthogonal ECF-based switches and devices for controlling complex expression programs in B. subtilis, based on novel actinobacterial ECF groups. The success of this project, set at the interface between basic molecular research and SynBio application, furthermore builds on the applicant’s strong expertise in bacterial genetics, the superb infrastructure of the research environment at the LMU Biocenter, and the support provided to the applicant by the host institution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- engineering and technology industrial biotechnology metabolic engineering
- natural sciences biological sciences synthetic biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
01069 Dresden
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.