Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease: the PREDIMED PLUS Study

Projektinformationen

PREDIMED PLUS

ID Finanzhilfevereinbarung: 340918

Projekt abgeschlossen

Startdatum 1 Mai 2014

Enddatum 30 April 2019

Finanziert unter

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 2 078 969,62

EU-Beitrag € 2 078 969,62

Koordiniert durch

UNIVERSIDAD DE NAVARRA
Spain

Ziel

The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial.

Wissenschaftliches Gebiet

• social sciences › sociology › demography › mortality
• engineering and technology › materials engineering › composites
• medical and health sciences › health sciences › nutrition
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases

Programm/Programme

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health

Aufforderung zur Vorschlagseinreichung

ERC-2013-ADG
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-AG - ERC Advanced Grant

Gastgebende Einrichtung

UNIVERSIDAD DE NAVARRA

Hauptforscher

Miguel ángel Martínez González (Prof.)

Kontakt Verwaltung

Fco. Javier Irigoyen Barrio (Mr.)

• EU-Beitrag: € 1 496 754,47
• Adresse: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL ; 31080 Pamplona ; Spanien
• Region: Noreste › Comunidad Foral de Navarra › Navarra
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

Begünstigte (2)

UNIVERSIDAD DE NAVARRA

Spanien

Hauptforscher

Miguel ángel Martínez González (Prof.)

Kontakt Verwaltung

Fco. Javier Irigoyen Barrio (Mr.)

• EU-Beitrag: € 1 496 754,47
• Adresse: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL ; 31080 Pamplona
• Region: Noreste › Comunidad Foral de Navarra › Navarra
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

Spanien

Kontakt Verwaltung

Manuel Sanchez (Mr.)

• EU-Beitrag: € 582 215,15
• Adresse: CALLE MONFORTE DE LEMOS 5 ; 28029 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten