Objective
In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children.
Different therapeutic interventions for male infertility have to be developed depending on the severity of germ cell deficits in individual patients. In cases where undifferentiated germ cells are present in the testis, strategies based on sperm development from spermatogonial stem cells (SSCs) in vitro or in vivo need to be established. However, if no germ cells are present in the testis, somatic cells of such patients will be the only option from which to develop their own sperm. Development of these potential therapies requires detailed understanding of the entire process of sperm production from stem cells through to functional sperm. This information is still incomplete and fragmented.
The current proposal seeks to train young scientists in a network that joins together the complementary knowledge and expertise of several public and private EU partners from disciplines of physiology, cell biology, molecular biology, chemistry and medicine in the field of male reproduction to investigate three strategies for sperm development: (1) propagation of human SSCs in vitro followed by their transplantation, (2) sperm development in vitro from stem cells or early germ cells, (3) sperm development in human testis tissue grafts in vivo.
By coaching young scientists in this inter-sectorial and multidisciplinary network, we will train the next generation of researchers within the EU who are then primed to become leaders in the field of male fertility that continue to investigate basic science and translational aspects leading to novel interventions and clinical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine andrology
- social sciences sociology demography fertility
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine physiology
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-ITN
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1105AZ Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.