Objectif "Plant roots interact with a huge diversity of soil residing microbes that improve or hamper plant development. In a changing agriculture, where chemical inputs have to be reduced to protect the environment, the use of beneficial microbes residing in soil to improve plant nutrition and to prevent diseases is a promising alternative. However, symbiotic and pathogenic microbes follow similar steps to colonize their hosts and little is known about the extent of commonalities in plant responses guiding outcome of these associations. A cornerstone in regulation of these processes is the perception of microbial derived signals. Several genes required for sensing of mycorrhizal symbionts and subsequent colonization have been shown to affect interaction with root pathogens. We recently demonstrated in Dr. Schornack’s lab that a mutant of SymRK receptor which is unable to develop mycorrhization show extensive colonization by the root pathogenic oomycete Phytophthora palmivora. As this gene is the most upstream element in the signalling cascade required for mycorrhiza, we can now hypothesize an unsuspected convergence of early signalling events relayed and integrated by this protein to promote microbial accommodation or rejection. I will decipher how SymRK exerts roles in both interactions using a combination of approaches consisting of phenotyping of SymRK knock-out and overexpressing plants challenged with P. palmivora, mycorrhizal fungi and their isolated molecular signatures. The SymRK dependent transcriptomes in response to symbiotic or pathogenic signals and to the invasion will be elucidated to get clues about the gene network downstream of SymRK controlling synergistically or antagonistically these interactions. Finally I will take advantage of my environment in the Sainsbury Laboratory of Cambridge University to perform cutting edge microscopy on the cellular dynamics of receptors required for symbiosis including SymRK." Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiologymycologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesbiological behavioural sciencesethologybiological interactionsagricultural sciencesagriculture, forestry, and fisheriesagriculture Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2013-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution de l’UE € 231 283,20 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Royaume-Uni Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Renata Shaeffer (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée