Activity-Dependent Maturation of Inhibitory Processing in the Spinal Dorsal Horn

Projektinformationen

ADMIP

ID Finanzhilfevereinbarung: 624861

Abgeschlossenes Projekt

Startdatum 1 März 2015

Enddatum 1 Oktober 2018

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 294 219,60

EU-Beitrag € 294 219,60

Koordiniert durch

UNIVERSITY COLLEGE LONDON
United Kingdom

Ziel

In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus. This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening. We have recently shown that neonatal hypersensitivity to touch is due to the late maturation of glycinergic inhibitory signalling and that this signalling, in turn, requires nociceptive activity in the dorsal horn at a critical postnatal period. However, the phenotype of the interneurons involved and the mechanism for their maturation remains to be determined. Parvalbumin expressing neurons form a subgroup of inhibitory interneurons that express both GABA and glycine and are involved in the control of innocuous afferent input in the adult dorsal horn making them a key target for this process. Our pilot data shows that parvalbumin is not expressed in the dorsal horn until the second postnatal week, coinciding with the behavioural decrease in touch-hypersensitivity. Using a combination of cutting edge targeted genetic manipulations and in vivo electrophysiological recordings of dorsal horn neurons, this project will identify which populations of interneurons inhibit tactile activity in the neonatal and adult dorsal horn and which primary afferent inputs drive their activity-dependent maturation. This data will provide fundamental biological knowledge required for better management of infants in intensive care.

Wissenschaftliches Gebiet

• medical and health sciences › medical biotechnology › genetic engineering
• medical and health sciences › clinical medicine › obstetrics › postnatal care

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2013-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2013-IOF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IOF - International Outgoing Fellowships (IOF)

Koordinator

UNIVERSITY COLLEGE LONDON

Kontakt Verwaltung

Daniele Giannone (Mr.)

• EU-Beitrag: € 294 219,60
• Adresse: GOWER STREET ; WC1E 6BT London ; Vereinigtes Königreich
• Region: London › Inner London — West › Camden and City of London
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten