Cel In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus. This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening. We have recently shown that neonatal hypersensitivity to touch is due to the late maturation of glycinergic inhibitory signalling and that this signalling, in turn, requires nociceptive activity in the dorsal horn at a critical postnatal period. However, the phenotype of the interneurons involved and the mechanism for their maturation remains to be determined. Parvalbumin expressing neurons form a subgroup of inhibitory interneurons that express both GABA and glycine and are involved in the control of innocuous afferent input in the adult dorsal horn making them a key target for this process. Our pilot data shows that parvalbumin is not expressed in the dorsal horn until the second postnatal week, coinciding with the behavioural decrease in touch-hypersensitivity. Using a combination of cutting edge targeted genetic manipulations and in vivo electrophysiological recordings of dorsal horn neurons, this project will identify which populations of interneurons inhibit tactile activity in the neonatal and adult dorsal horn and which primary afferent inputs drive their activity-dependent maturation. This data will provide fundamental biological knowledge required for better management of infants in intensive care. Dziedzina nauki medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesclinical medicineobstetricspostnatal care Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator UNIVERSITY COLLEGE LONDON Wkład UE € 294 219,60 Adres GOWER STREET WC1E 6BT London Zjednoczone Królestwo Zobacz na mapie Region London Inner London — West Camden and City of London Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Daniele Giannone (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
