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Content archived on 2024-06-18

Biomarkers and underlying mechanisms of vulnerability to depression

Objective

Depression is the leading chronic condition in Europe and fourth leading cause of mortality woldwide. Depression is twice more common in women compared with men, associated with dysregulation of steroid hormones in the HPA-HPG axis, ovarian dysfunction, obesity, and very recently, prenatal stress, but the mechanisms underlying its development are not well understood, yet. The current project aims to identify early hormonal and neuroimaging biomarkers and explain underlying mechanisms of vulnerability to depression. The use of novel methods in both neuroimaging and statistics on an extensive longitudinal dataset should make considerable progress possible.
The applicant is moving from the University of Nottingham, UK, to the Central European Institute of Technology (CEITEC), the Czech Republic to use data from clinicaly healthy young adults collected in the European Longitudinal Study of Children and Parents (ELSPAC). Her experience with population-based studies, neuroimaging, and psychoneuroendocrinology as well as her collaboration with Harvard Medical School and Rotman Research Institute at Baycrest in Toronto complement with the experitse of CEITEC researchers in structural, functional, and effective connectivity analyses. Enriching the ELSPAC dataset with neuroimaging and saliva samples will increase the potential of this unique study, and attract new collaborators and students. Having access to such a dataset as well as mastering the methods for studying brain connectivity would be an asset for applicant’s career development.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2013-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

Masarykova univerzita
EU contribution
€ 146 005,20
Address
Zerotinovo namesti 9
601 77 Brno
Czechia

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Region
Česko Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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