Objective Cancer is a major health problem due to the failure of current therapies to effectively eradicate the disease. Alternative signaling pathways compensate for a therapeutically targeted pathway, a process referred to as 'evasive resistance'. The identities of the alternative signaling pathways and functional interconnections that underlie evasive resistance remain widely unknown. We propose to integrate cutting-edge clinical, molecular, and computational sciences to understand the signaling defects that allow tumors to evade therapy. With its synergistic, interdisciplinary approach, the proposed project is, to our knowledge, unique in Europe and possibly worldwide.Within the framework of rigorously designed clinical studies, a clinician will provide basic research scientists with diseased tissue isolated before therapy, during treatment or at the time of tumor progression. The tissue, chosen based on medical importance, accessibility to repeated sampling, and ethical considerations, will be from hepatocellular carcinoma. Tumor tissue will be obtained by needle biopsy and snap frozen to preserve in vivo properties. The basic research scientists and a computational biologist will determine, characterize and model the underlying signaling defects. Importantly, using longitudinal clinical samples in combination with mouse and cellular HCC model systems, we will seek to define treatment-related changes in cell signaling that allow tumors to circumvent therapy. This process will be iterative such that changes in treatment strategies will again be monitored in the same patient or experimental model. Insights gained will be used (i) to understand mechanisms of evasive resistance, (ii) to identify novel drug targets and predictive biomarkers, and (iii) to rationally design personalized medicine that ultimately increases therapeutic effectiveness and reduces financial burden. This innovative, comprehensive endeavor will improve diagnosis, treatment and clinical outcome. Fields of science natural sciencesbiological sciencescell biologycell signalingnatural sciencescomputer and information sciencescomputational sciencemedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencespersonalized medicine Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-2013-SyG - ERC Synergy Grant Call for proposal ERC-2013-SyG See other projects for this call Funding Scheme ERC-SyG - Synergy grant Lead Principal Investigator Michael N. Hall Prof. Host institution UNIVERSITAT BASEL EU contribution € 5 491 133,20 Address PETERSPLATZ 1 4051 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Principal investigator Michael N. Hall (Prof.) Administrative Contact Kurt Kamber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAT BASEL Switzerland EU contribution € 5 491 133,20 Address PETERSPLATZ 1 4051 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Principal investigator Michael N. Hall (Prof.) Administrative Contact Kurt Kamber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 3 026 778,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Niko Beerenwinkel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSSPITAL BASEL Switzerland EU contribution € 2 679 970,80 Address HEBELSTRASSE 32 4031 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Markus Heim (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
