Cel Expectations about health and disease induce immune and endocrine responses and directly affect health and treatment outcomes. However, there is an urge to understand the mechanical underpinnings how expectations affect immune and endocrine responses and how this knowledge can be used for therapeutic interventions.My research group studies the main expectancy learning mechanisms for itch and pain as a generic expectancy model across symptoms and conditions. We recently showed that dual expectancy learning processes (i.e. conditioning and suggestions) are most powerful for itch symptoms, corresponding with findings for other symptoms and conditions. Based on these studies, I propose a groundbreaking dual expectancy learning approach, testing whether combined expectancy learning processes (i.e. both conditioning and suggestions, offered with personalized cues and exposure to relevant stressors) affect most profoundly the immune and endocrine system, in turn affecting health and disease outcomes.The major aim is to unravel the central mechanisms of how peoples’ expectations affect immune and endocrine responses and related health outcomes, through the use of pioneering multidisciplinary methods in healthy and clinical populations. First, we systematically train immune and endocrine responses and relate them to psychological, neurobiological and genetic mechanisms. Second, we test these manipulations for physical health challenges (e.g. inflammatory or allergic histamine reactions) in healthy subjects and patients. Third, we study the long-term effects in chronic inflammatory itch and pain conditions (e.g. replacing anti-inflammatory pharmacotherapies, reducing side effects).This interdisciplinary, cross-boundary project progresses key theoretical knowledge of the central expectation mechanisms for immune and endocrine responses. Findings open new horizons for health prevention and therapeutic interventions for various inflammatory conditions and physical symptoms. Dziedzina nauki medical and health sciencesclinical medicineendocrinology Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-CG-2013-SH4 - ERC Consolidator Grant - The Human Mind and its Complexity Zaproszenie do składania wniosków ERC-2013-CoG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-CG - ERC Consolidator Grants Instytucja przyjmująca UNIVERSITEIT LEIDEN Wkład UE € 1 981 009,00 Adres RAPENBURG 70 2311 EZ Leiden Niderlandy Zobacz na mapie Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny R.J. Oosterloo Mpa (Dr.) Kierownik naukowy Andrea Evers (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITEIT LEIDEN Niderlandy Wkład UE € 1 981 009,00 Adres RAPENBURG 70 2311 EZ Leiden Zobacz na mapie Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny R.J. Oosterloo Mpa (Dr.) Kierownik naukowy Andrea Evers (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych