Objective
This project's main objective is to study the role of the CD300 receptor family in the pathogenesis of the infection by human immunodeficiency virus (HIV) and viral escape mechanisms. We will use peripheral blood samples from patients chronically infected with HIV as well as from healthy donors. The samples will be collected in hospitals of the Basque Country, Spain. The experimental part will be performed at BioCruces Health research Institute-Cruces University Hospital. The expression of the CD300 receptors will be determined by flow cytometry techniques in cells from peripheral blood from patients and healthy subjects, and correlations studies will be performed with markers of chronic inflammation. It will be studied the CD300a inhibitory receptor in CD8+ T cells in great detail, with a particular emphasis on its participation in the processes of cell exhaustion, which is defined by the loss of effector functions and proliferative capacity of memory T cells. Finally, we will determine the degree of translocation of phosphatidylserine and phosphatidylethanolamine, the two ligands of the CD300a inhibitory receptor, into the outer leaflet of the plasma membrane in HIV-infected cells, and their involvement in the functional recognition by HIV specific CD8+ T cells and by NK cells. We will use recombinant viruses to infect cell lines and primary cells. We believe that the results that we will obtain can be of prognostic value and it will help to identify new targets for the treatment of this disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
48903 BARAKALDO BIZKAIA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.