Cel This proposal targets the development of self-assembling nanoscale systems to bind heparin. Heparin is widely used as an anti-coagulant during major surgery, but once surgery is complete, it is necessary to remove the heparin and allow clotting to begin. The current therapy is protamine, a protein extracted from shellfish which acts as a powerful heparin binder, but unfortunately, causes allergic response and other problems in significant numbers of patients (ca. 10%). We are therefore targeting the development of novel synthetic nanoscale protamine replacements which may avoid some of these difficulties. Our unique strategy is to develop small molecules which self-assemble into nanoscale heparin binders. This has the advantage of being highly tunable and uses low molecular-weight (drug-like) building blocks – allowing structure-activity relationship understanding of the binding event to emerge. The self-assembled structures will be optimised in terms of their charge density, morphology, display of functional groups and ability to degrade, to maximise heparin binding and surgical potential. This project will provide fundamental insight into the requirements of an effective heparin binder. Our optimised systems will be tested in clotting and toxicity assays, and may have longer-term applications in a medical setting. Dziedzina nauki medical and health sciencesclinical medicinesurgerynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator UNIVERSITY OF YORK Wkład UE € 221 606,40 Adres HESLINGTON YO10 5DD York North Yorkshire Zjednoczone Królestwo Zobacz na mapie Region Yorkshire and the Humber North Yorkshire York Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Chris Barber (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
