Objective
The purpose of this fellowship application is to allow me to achieve research independence in the field of cancer genomics. To achieve this I believe that I need to develop a niche area of expertise and to enhance my research management and dissemination skills. This fellowship would enable me to realize these ambitions through five main objectives: (i) To obtain greater experience in research project management by managing the financial and research aspects of the fellowship, with advice from the Scientist in charge, and by attending career development courses run by the host institution. (ii) To conduct the proposed research project to understand the role of non-coding mutations in cancer. The consequences of mutations in non-coding regions of the genome are not well understood in comparison to coding sequences. At present, there are no methods available for the prioritization of somatic non-coding variants in tumour genomes. Therefore I propose to develop and validate a method to prioritize non-coding somatic mutations that could contribute to tumourigenesis. My approach will be to use data from multiple tumour genomes to estimate somatic mutations rates across the non-coding genome, adjusting for confounding effects, and to prioritize regions with a high somatic mutation rate and with high evolutionary conservation. My hypothesis is that regions of the genome that are recurrently mutated in tumours and under evolutionary constraint are likely to be functionally relevant in cancer. (iii) To acquire a deeper understanding of the processes involved in genomic evolution by working with the Scientist in Charge. (iv) To develop my dissemination and outreach skills and activities by lecturing, supervising students and engaging with the public. (v) To apply for independent funding focusing in the niche of cancer evolution. I believe that as a Marie Curie Fellow I can accomplish these goals thus allowing me to embark on a successful independent research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.