Objective
Inflammatory Bowel Diseases (IBD) are chronic disorders for which aetiology is unknown and only palliative care is available for patients. In Europe, 2.2 million people suffered of ulcerative colitis or Crohn's disease in Europe, the socio-economic impact of IBD is very heavy. Thus, the development of new and more effective treatments for IBD depends upon a better understanding of the regulation of inflammatory response.
The aims of this project are both: firstly, provide evidence of contribution of secreted elastase from intestinal epithelial cells (IEC) to over activation of macrophages in IBD and establish molecular actors of this crosstalk; secondly decipher the protective properties against colitis of ELAFIN, an elastase inhibitor, through modulation of macrophage activities. The fellow will develop in vitro and in vivo experiments to establish the role of elastolytic balance in the dialog between IEC and macrophages in relation to IBD.
Our data raise the possibility that intestinal IEC are major regulators of proteolytic homeostasis by secreting proteases and protease inhibitors, which then can interfere with all biological functions of the gut, including immune functions. In IBD, secreted hyperactive elastase could participate to the dialogue between epithelium and other mucosal cells such as macrophages. Our analysis of elastase homeostasis aims to identify control points in the mechanisms of disease that could be addressed by development of a novel therapeutic approach for IBD.
The fellow holds a junior investigator position at a French Institution. This program will allow her to develop complementary and transferable skills and to successfully build-up and conduct a ground-breaking research project in the field of human digestive health. This foreign experience is a necessary step on the road to complete independence for her. Thanks to this program, she would be in an optimal position to create an independent research group upon her return to Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.