Objective
This project asks ‘Do oxytocin and dopamine systems interact in the human brain?’. It will encompass an innovative, inter- disciplinary method combining established techniques in neuropharmacology, neuroimaging and genetics. It will use a mentalizing (social dilemma) task where it is hypothesized that the trust-eliciting reward value of mutual cooperation is coded by both dopaminergic and oxytocinergic actions in the striatum. Support for this comes from dopamine´s well-characterized role in reward learning and oxytocin’s recently found impact on affiliate and cooperative behavior and its neurocorrelates. As a way of assessing these systems, I will combine, for the first time, oxytocin and dopamine manipulations; as well as integrate information from natural genetic variability to further support my predictions. The underlying assumption is that acute changes in their striatal levels as well as chronic predispositions affecting their systems can influence striatal activation during social reward processing. (Chronic predispositions arising from environmental historical events and personality will also be taken into account.)
There is robust evidence that interplay between the dopamine and the oxytocine systems is crucial for social cognition from animal studies, however this has not yet been investigated in humans. The question is paramount and timely as mental illness enigmas involving trust/paranoia, social avolition and anxiety or drug addiction are still unresolved and new oxytocinergic therapies are now being clinically trialed for autism and schizophrenia (and partially to complement dopaminergic ones, as in the case of the latter). The ultimate goal herein is to inform the rational design of treatments for these conditions by better understanding the biological underpinnings of human social cognition, in respect to trust and social behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
1749 016 Lisbon
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.