Objetivo By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of somatic evolution. The evolution of cancer tumors in a body can be likened with the evolution of populations in more or less fragmented habitats. The tumor is usually a expanding population of clonal cells, which may differentiate to a bigger or lesser extent (population structure) and disperse to contiguous (range expansion) or more distant tissues (long distance colonization). During tumor progression, this population of cells is subject to distinct somatic evolutionary processes like mutation, drift, selection or migration, which can act at different points in time and geographical space. Very recently, the discovery of extensive intratumor heterogeneity, together with the rise of single cell genomics, has created an unique opportunity to study the phylogeography of cancer tumor cells. So far evolutionary inferences drawn from cancer genomes have been mostly qualitative. Here we propose to study a thousand single cell genomes from different regions in primary tumors and matched metastases. We will develop and apply state-of-the-art statistical and computational techniques from phylogenetics, phylogeography and population genomics to understand the tempo and mode of evolution of cell lineages within and between cancer tumors. By doing so we aim to construct a robust theoretical and methodological evolutionary framework that can contribute to a better understanding of the process of somatic evolution and shed light into the biology of cancer. Ámbito científico natural sciencesbiological sciencesevolutionary biologynatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-CG-2013-LS8 - ERC Consolidator Grant - Evolutionary, Population and Environmental Biology Convocatoria de propuestas ERC-2013-CoG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-CG - ERC Consolidator Grants Institución de acogida UNIVERSIDAD DE VIGO Aportación de la UE € 1 481 399,60 Dirección LG CAMPUS LAGOAS MARCOSENDE 36310 Vigo Pontevedra España Ver en el mapa Región Noroeste Galicia Pontevedra Tipo de actividad Higher or Secondary Education Establishments Investigador principal David Posada Gonzalez (Prof.) Contacto administrativo Anxo Moreira González (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSIDAD DE VIGO España Aportación de la UE € 1 481 399,60 Dirección LG CAMPUS LAGOAS MARCOSENDE 36310 Vigo Pontevedra Ver en el mapa Región Noroeste Galicia Pontevedra Tipo de actividad Higher or Secondary Education Establishments Investigador principal David Posada Gonzalez (Prof.) Contacto administrativo Anxo Moreira González (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA España Aportación de la UE € 61 250,00 Dirección Hospital Clínico Universitario. Edif. consultas planta -2. Choupana s/n 15706 Santiago de Compostela Ver en el mapa Región Noroeste Galicia A Coruña Tipo de actividad Research Organisations Contacto administrativo Esther Sande (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos FUNDACIO PARC CIENTIFIC DE BARCELONA La participación finalizó España Aportación de la UE Sin datos Dirección BALDIRI I REIXAC 4 08028 Barcelona Ver en el mapa Región Este Cataluña Barcelona Contacto administrativo Marta Molina Gómez (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos FUNDACIO CENTRE DE REGULACIO GENOMICA España Aportación de la UE € 457 250,00 Dirección CARRER DOCTOR AIGUADER 88 08003 Barcelona Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Research Organisations Contacto administrativo Pedro Corral (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
