Objective
Within BMP4EAC we aim to investigate the commercial feasibility of our newly discovered and highly specific antibodies against BMP4 and one of its receptors, BMPR1a, for imaging applications in oncology. BMP4 and BMPR1a are highly expressed in esophageal adenocarcinoma (EAC) and other tumors as well as their metastases. The specificity, strong binding capacity, rapid clearance, high tissue penetration level, and flexibility of our antibodies is unprecedented and makes them highly suitable for in vivo imaging applications.
The opportunity: The current methods for evaluation of disease stage consist of diverse modalities, including, CT and PET-CT scans, and ultrasonography. These techniques have major limitations to accurately detect metastasis and are inadequate for monitoring disease response. In the clinical setting we foresee applications of our proprietary technology in the non-invasive diagnosis of tumors and metastases with high expression of BMP4 and/or BMPR1a (e.g. EAC), identification of patients with high chance to respond to BMP4 inhibitors, follow tumor progression during treatment, and facilitated localization of small metastases during surgical treatment. Furthermore, the labeled antibodies can be used to investigate the efficacy of novel therapeutic agents by following tumor progression in animal models in a research setting.
The project and expected outcomes: Within the ERC PoC we will explore the commercial feasibility by in vivo validation experiments as well as by performing essential research for the formulation of a business proposition, strengthening our IP position, and developing a sound business plan. These activities will result in a proposition package that will be used to present the commercial potential to investors and other strategic partners to attract funding after completion of the ERC PoC and potentially even initiate licensing and partnership deals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-PoC
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
1105AZ Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.