Objective
Metastasis is responsible for > 90% of cancer-related deaths. Billions of dollars have been spent trying to cure primary tumors but very little was spent in trying to detect or kill the highly aggressive tumor cells that cause disease spreading. One of the reasons is that single cell studies of rare cells in blood still present a large challenge. Single cell analysis remains tedious with many different instruments and protocols, typically taking a few days of hands-on work. This slows down research, but also hinders the translation to application in future clinical practice. In SCALPEL, we envisage a high-content, high-throughput cell imaging and sorting platform, more compact and easier to use than any existing single cell analyzer. The high content results from lensfree digital imaging of single cells on a high speed CMOS active optical pixel matrix to analyze the morphology of cells. The high throughput results from a highly parallelized fluidic matrix that steers cells at high speed over the CMOS imaging blocks. Lensfree cell sorters can be realized in a cheap and compact platform, as all optomechanical components (lenses, detectors, nozzles,...) are replaced by nanoelectronics, advanced imaging and signal processing technology.
SCALPEL aims to perform a full feasibility study of this concept and will require to investigate the ultimate limits in: 1) maximizing image resolution and sensitivity to single cell morphological features obtained via lensfree holographic imaging; 2) maximizing cell manipulation speed in microfluidic systems via a high degree of parallelization; and 3) digital image signal processing with extremely low latency at reasonable power consumption. If this multidisciplinary complexity can be understood, we will have built the components for different versions of compact cytometers that can be used at hand of pathologist, surgeons, and nurses for improving the individualized follow-up and survival rate of cancer patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- social sciences media and communications graphic design
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering signal processing
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nanoelectronics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
3001 Leuven
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.