Cel Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages.The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs can modulate the phenotype of target cells is an emerging paradigm in the intercellular communication. The extracellular RNAs are thus now considered as paracrine/endocrine signals. EVs contain diverse species of RNAs (mRNA, miRNAs and long non-coding RNAs) reflecting the functional state of the cell of origin. Recent studies on adult stem cell-induced tissue regeneration pointed out paracrine/endocrine mechanisms rather than permanent engraftment and trans-differentiation of stem cells. Therefore, the paracrine/endocrine hypothesis has changed the perspective of the therapeutic use of stem cells in regenerative medicine. Additionally, several studies indicate that EVs play a relevant role as mediators of stem cell induced regeneration by reprogramming injured cells.Within this project, we will explore the different necessary aspects in order to get a more profound knowledge on EVs, on their mechanisms of action in tissue injury, and on the definition of the most promising “active biological ingredients” of their content to further promote EV as new potential therapeutic strategies in the field of regenerative medicine. Also, within the EVStemInjury project, two different approaches of EV production will be explored: Biological and Synthetic, showing the different potential design strategies and to assess their efficiency. Finally, in order to explore the renoprotective effect of EVs, developed within the project, ranging from toxic, ischemic and reperfusion models, we will use a large number of experimental in vitro as in vivo models of acute kidney injury. Dziedzina nauki medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesclinical medicinenephrologykidney diseases Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IAPP Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Koordynator BIOINDUSTRY PARK SILVANO FUMERO SPA SOCIETA'BENEFIT Wkład UE € 446 506,53 Adres VIA RIBES 5 10010 Colleretto Giacosa Włochy Zobacz na mapie Region Nord-Ovest Piemonte Torino Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Alberto Baldi (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko LONDON METROPOLITAN UNIVERSITY Zjednoczone Królestwo Wkład UE € 300 427,81 Adres HOLLOWAY ROAD 166 220 N7 8DB London Zobacz na mapie Region London Inner London — East Haringey and Islington Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Jameel Inal (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAIR MEDISCH CENTRUM UTRECHT Niderlandy Wkład UE € 191 513,53 Adres HEIDELBERGLAAN 100 3584 CX Utrecht Zobacz na mapie Region West-Nederland Utrecht Utrecht Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Raymond M Schiffelers (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Hiszpania Wkład UE € 216 776,91 Adres CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona Zobacz na mapie Region Este Cataluña Barcelona Rodzaj działalności Other Kontakt administracyjny Pastora Martinez Samper (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych FRESENIUS MEDICAL CARE ITALIA SPA Zakończenie uczestnictwa Włochy Wkład UE € 94 522,45 Adres VIA CREMA 8 26020 PALAZZO PIGNANO Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Ciro Tetta (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych