Objective
Stem cells (SCs) ensure the development of the different tissues during morphogenesis, their physiological turnover during adult life and tissue repair after injuries. .
Our lab has recently developed new methods to study by lineage tracing the cellular hierarchy that sustains homeostasis and repair of the epidermis and to identify distinct populations of SCs and progenitors ensuring mammary gland and prostate postnatal development.
While quantitative clonal analysis combined with mathematical modeling has been used recently to decipher the cellular basis of tissue homeostasis, such experimental approaches have never been used so far in mammals to investigate the cellular hierarchy acting during tissue expansion such as postnatal development and tissue repair.
In this project, we will use a multi-disciplinary approach combining mouse genetic lineage tracing and clonal analysis, mathematical modeling, proliferation kinetics, transcriptional profiling, and functional experiments to investigate the cellular and molecular mechanisms regulating tissue expansion during epithelial development and tissue repair and how the fate of these cells is controlled during this process.
1. We will define the clonal and proliferation dynamics of tissue expansion in the epidermis, the mammary gland and the prostate during postnatal growth and adult tissue regeneration.
2. We will define the clonal and proliferation dynamics of tissue expansion in the adult epidermis following wounding and mechanical force mediated tissue expansion.
3. We will define the mechanisms that regulate the switch from multipotent to unipotent cell fate during development of glandular epithelia.
Defining the cellular and molecular mechanisms underlying tissue growth and expansion during development and how these mechanisms differ from tissue regeneration in adult may have important implications for understanding the causes of certain developmental defects and for regenerative medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine physiology homeostasis
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
1050 Bruxelles / Brussel
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.