Objective
"Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer mortality in women worldwide. The recently identified Receptor Activator of Nuclear Factor (NF)-κB (RANK)-axis has stimulated novel research in the field of breast cancer etiology, treatment, and prevention. Experimental data implicate RANK signalling in mammary tumor development. Preliminary human data show increased RANK expression correlated with poor outcome, and circulating concentrations of osteoprotegerin, the decoy RANK receptor inhibiting RANK-axis signalling, are increased in several conditions associated with decreased risk of breast cancer (e.g. pregnancy).
The proposed research will provide the first evidence on the role of pre-diagnosis RANK-axis members in the etiology of breast cancer in the EPIC cohort, the largest prospective breast cancer case-control study worldwide, and in a complementary study in the unique Finnish Maternity Cohort. A RANK-inhibitor is clinically available and these studies have the potential to inform primary prevention trials. The research will be completed at the internationally recognized German Cancer Research Center (DKFZ).
The fellow`s knowledge transfer objectives capitalize on almost a decade of research experience and established networks in U.S. pregnancy cohorts and Harvard University`s Nurses` Health Study. The fellow will: (1) Promote scientific exchange with U.S.-based cohorts and provide subject area expertise; (2) Broaden data analysis expertise at DKFZ to foster long-term collaborations among colleagues; and, (3) Lead and initiate cancer research projects and form strategic professional networks with European colleagues to develop ongoing collaborations.
The novel research will strengthen DKFZ`s position as a center for innovative research in cancer epidemiology and the fellowship provides a unique opportunity to reinforce and expand collaborations between scientists at DKFZ and U.S. institutions."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences data science
- social sciences sociology demography mortality
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine obstetrics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.