Obiettivo Liver fibrosis is a progressive and fatal disease characterized by the accumulation of excessive amounts of scar tissue in response to chronic liver injury. The disease proceeds asymptomatically, until clinical signs of liver failure occur only in a very late stage of the disease. Early diagnosis would offer better treatment options. However, early detection and quantification of fibrosis, as well as determining the rate of fibrosis progression (fibrogenesis) or reversal (fibrolysis) still depends on rudimentary and inaccurate methods. This proposal focuses on the development of a new method for the quantification of liver fibrosis and its dynamics, based on the design of molecular probes that can selectively pinpoint these processes in non-invasive imaging studies. To this end, novel disease markers of fibrosis, fibrogenesis and fibrolysis will be identified using state-of-the-art proteomic techniques, simultaneously taking into account that these markers will have to be easily accessible for intravenously-injected ligands in vivo. Based on the identified markers, binding probes will be synthesized and evaluated for their detection capabilities in fibrosis models. To this end, whole body imaging studies are used, combined with novel pharmacokinetic-modeling approaches, in which body distribution, cellular uptake and excretion of the new probes are correlated to disease parameters. Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-4-1.IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2007-4-1-IOF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IOF - International Outgoing Fellowships (IOF) Coordinatore RIJKSUNIVERSITEIT GRONINGEN Contributo UE € 229 076,70 Indirizzo Broerstraat 5 9712CP Groningen Paesi Bassi Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Simon K. Kuipers (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto PRESIDENT AND FELLOWS OF HARVARD COLLEGE Stati Uniti Contributo UE Nessun dato Indirizzo MASSACHUSETTS AVENUE 1350 02138 Cambridge Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Detlef Schuppan (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato