Objective
The detection of DNA hybridization and protein recoginittion event (immunoassay) is very important for the diagnosis and treatment of genetic diseases, for the detection infectious agents and for reliable forensic analysis. Recent activity has focused on the development of hybridization assays that permit simultaneous determination of multiple DNA or protein targets, using optical or electrochemical coding technology, based on unique encoding properties of semiconductor crystal nanoparticle tags (quantum dots). Described multi-target bio assays were performed in batch mode, involving significant amount of steps, connected with the possibility of human error, time and reagents consuming. Lab-on-a-chip technology offers tremendous potential for obtaining desired analytical information in a simpler, faster and cheaper way compared to traditional batch/laboratory-based technology. Particularly attractive for multiple DNA and protein recognition applications (i.e. point-of-care) is the high-throughput, automation, versatility, portability, reagent/sample economy and high-performance of such micromachined devices. Overall objective of the proposed research is to create and characterize a portable microanalyzer, based on a novel advanced Lab-on-a-Chip technology with magnetic separation and end-column quantum dots tracers voltammetric detection of multiple DNA and protein targets for point-of-care , automated, high-throughput, sensitive, selective and simultaneous assays. The new micro-total analytical system will rely on coupling of microfluidic transport of samples, effective flow-through magnetic separation complementary/non-complementary DNA and protein targets and a novel chip-based voltammetric stripping detection of quantum dot tags. To successfully complete such advanced micro-total analytical system, several fundamental and practical issues will be addressed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- engineering and technology other engineering and technologies microtechnology lab on a chip
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences electromagnetism and electronics semiconductivity
- medical and health sciences other medical sciences forensic sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2009-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.