Objective This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies. Fields of science natural sciencesbiological sciencesgeneticsDNA Keywords lung growth lung function decline COPD cohorts risk factors Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) PHC-01-2014 - Understanding health, ageing and disease: determinants, risk factors and pathways Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2014-two-stage Funding Scheme RIA - Research and Innovation action Coordinator IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Net EU contribution € 2 567 232,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 567 232,50 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY OF BRISTOL United Kingdom Net EU contribution € 401 243,75 Address BEACON HOUSE QUEENS ROAD BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 401 243,75 FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Spain Net EU contribution € 496 026,00 Address C ROSSELLO 132 PLANTA 05 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 496 026,25 UNIVERSITETET I BERGEN Norway Net EU contribution € 434 243,00 Address MUSEPLASSEN 1 5020 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 037 018,75 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. HELSE BERGEN HF Norway Net EU contribution € 115 757,00 Address JONAS LIES VEI 65 5021 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 115 757,50 UNIVERSITY OF SOUTHAMPTON United Kingdom Net EU contribution € 394 712,50 Address Highfield SO17 1BJ Southampton See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 394 712,50 SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT Switzerland Net EU contribution € 0,00 Address KREUZSTRASSE 2 4123 Allschwil See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 903 391,25 UNIVERSITA DEGLI STUDI DI VERONA Italy Net EU contribution € 405 000,00 Address VIA DELL ARTIGLIERE 8 37129 Verona See on map Region Nord-Est Veneto Verona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 405 000,00 LANDSPITALI UNIVERSITY HOSPITAL Iceland Net EU contribution € 125 000,00 Address Eiriksgata 5 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 125 000,00 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 215 880,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 215 880,00 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany Net EU contribution € 379 000,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 379 000,00 UNIVERSITY OF MELBOURNE Australia Net EU contribution € 0,00 Address PARKVILLEOFFICE OF THE VICE CHANCELLOR 3010 Melbourne See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 346 928,75