Objective
Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesgeneticsDNA
- natural sciencescomputer and information sciencesdata sciencedata mining
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencesbiological sciencesgeneticsmutation
- natural sciencesbiological sciencesgeneticsgenomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback.
You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Topic(s)
Call for proposal
(opens in new window) H2020-PHC-2014-2015
See other projects for this callSub call
H2020-PHC-2014-two-stage
Funding Scheme
RIA - Research and Innovation actionCoordinator
3000 Leuven
Belgium
See on map
Participants (16)
9000 Gent
See on map
18055 Rostock
See on map
SW7 2AZ LONDON
See on map
10117 Berlin
See on map
00271 Helsinki
See on map
8000 Aarhus C
See on map
46980 Paterna
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8092 Zuerich
See on map
19104 Philadelphia
See on map
14473 Potsdam
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
100084 BEIJING
See on map
1831 DIEGEM
See on map
00161 Roma
See on map
1118 BUDAPEST
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
51005 Tartu
See on map
17177 Stockholm
See on map