Objective Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks.New insights from (a)+(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.Key deliverables are:1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3)2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4)3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5)4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6)5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7)6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development Fields of science medical and health scienceshealth sciencespublic healthepidemiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineophthalmologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health scienceshealth sciencesnutrition Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) PHC-01-2014 - Understanding health, ageing and disease: determinants, risk factors and pathways Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2014-two-stage Funding Scheme RIA - Research and Innovation action Coordinator EBERHARD KARLS UNIVERSITAET TUEBINGEN Net EU contribution € 1 360 875,00 Address GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Germany See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 360 875,00 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands Net EU contribution € 962 250,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 962 250,00 FUNDACIO CENTRE DE REGULACIO GENOMICA Spain Net EU contribution € 360 000,00 Address CARRER DOCTOR AIGUADER 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 360 000,00 STICHTING RADBOUD UNIVERSITEIT Netherlands Net EU contribution € 539 375,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 539 375,00 UNIVERSITE DE BORDEAUX France Net EU contribution € 264 375,00 Address PLACE PEY BERLAND 35 33000 Bordeaux See on map Region Nouvelle-Aquitaine Aquitaine Gironde Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 416 875,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 152 500,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 152 500,00 UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 501 992,11 Address GOWER STREET WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 501 992,11 FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION Spain Net EU contribution € 320 531,00 Address CARRER HORACI 41/43 Esc B 08022 BARCELONA See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 320 531,25 PRO RETINA DEUTSCHLAND Germany Net EU contribution € 106 250,00 Address VAALSER STRASSE 108 52074 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 106 250,00 AYOXXA BIOSYSTEMS GMBH Germany Net EU contribution € 608 500,00 Address Nattermannallee 1 50829 Cologne See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 608 500,00 F. HOFFMANN-LA ROCHE AG Switzerland Net EU contribution € 0,00 Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 97 500,00 MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST Participation ended United Kingdom Net EU contribution € 124,38 Address CITY ROAD 162 EC1V 2PD London See on map Region London Inner London — East Haringey and Islington Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 124,38 FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P. Spain Net EU contribution € 198 607,50 Address AVENIDA AMERICO VESPUCIO 15 EDIF S2 41092 Sevilla See on map Region Sur Andalucía Sevilla Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 198 607,50 THE QUEEN'S UNIVERSITY OF BELFAST United Kingdom Net EU contribution € 592 116,01 Address UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast See on map Region Northern Ireland Northern Ireland Belfast Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 592 116,01 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland Net EU contribution € 5 000,00 Address BELFIELD 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 5 000,00