Obiettivo Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would complement currently available therapies to increase efficacy. The project applies recent compelling knowledge on the identity of the main antigen-presenting DC subsets for vaccine elicitation of cytotoxic T lymphocytes endowed with the ability to seek and destroy tumour cells (such immune mechanism is termed crosspriming). This unique opportunity for superior DCs for immunotherapy comes from the fact that Miltenyi, a successful European biotech company, has the necessary proprietary reagents (anti-BDCA-3 monoclonal antibody and immunomagnetic selection technology), as well as the expertise to clinically develop a strategy of DC isolation and short-term cell culture for immunotherapy. From the point of view of the tumor antigens, processed autologous tumor material will be mixed with defined common tumor antigens in the form of recombinant proteins. This novel combination will permit stronger and broader antitumor immune responses and more accurate monitoring of the ensuing immunity against the tumors. These features should make the novel DC vaccine more efficacious than the currently US-approved DC vaccine PROVENGE and other DCs preparations undergoing trials, such as those derived from monocytes. Three of the leading groups in immunotherapy of cancer in Europe would join forces to develop this individualized cell therapy technology in clinical trials for two highly prevalent and unsatisfactorily managed malignant conditions. Industrial partnership provides the unique advantage of producing a rigorously standardized product for eventual multicentre trials. Campo scientifico medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicinesurgerymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesmedical biotechnologycells technologies Programma(i) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Argomento(i) PHC-13-2014 - New therapies for chronic non-communicable diseases Invito a presentare proposte H2020-PHC-2014-2015 Vedi altri progetti per questo bando Bando secondario H2020-PHC-2014-two-stage Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Contribution nette de l'UE € 1 190 000,00 Indirizzo Avenida de pio xii 55 31008 Pamplona Spagna Mostra sulla mappa Regione Noreste Comunidad Foral de Navarra Navarra Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 190 000,00 Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto STICHTING RADBOUD UNIVERSITEIT Paesi Bassi Contribution nette de l'UE € 1 510 000,00 Indirizzo Houtlaan 4 6525 XZ Nijmegen Mostra sulla mappa Regione Oost-Nederland Gelderland Arnhem/Nijmegen Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 510 000,00 MILTENYI BIOTEC GMBH Germania Contribution nette de l'UE € 1 345 000,00 Indirizzo Friedrich ebert strasse 68 51429 Bergish gladbach Mostra sulla mappa Regione Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 345 000,00 CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) Spagna Contribution nette de l'UE € 655 000,00 Indirizzo Calle melchor fernandez almagro 3 28029 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 655 000,00 UNIVERSIDAD DE NAVARRA Spagna Contribution nette de l'UE € 1 050 000,00 Indirizzo Campus universitario edificio central 31080 Pamplona Mostra sulla mappa Regione Noreste Comunidad Foral de Navarra Navarra Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 050 000,00 CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Svizzera Contribution nette de l'UE € 0,00 Indirizzo Rue du bugnon 21 1011 Lausanne Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 216 250,00 UNIVERSITE DE LAUSANNE Svizzera Contribution nette de l'UE € 0,00 Indirizzo Quartier unil-centre bâtiment unicentre 1015 Lausanne Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 606 250,00