Cel How do we decide what to choose? While certain cues are preferred, others are avoided. But even innate preferences and aversions must be evaluated in a context-dependent manner. These contexts are environmental cues, but also internal state. In this proposal, I will address how the nervous system integrates chemosensory information with internal state to produce appropriate behaviors. I will present a research program relying on fly genetics, behavior analysis, and in vivo physiology to characterize the neural circuits and mechanisms involved in context-dependent processing of sensory cues. Specifically, I will address how three different internal states (hunger, mating state, sickness) change the perception and processing of odors and tastes.Together with my lab, I have previously demonstrated that the innately aversive odor CO2 is processed in a metabolic state-dependent manner in the fly brain. Exclusively in the context of hunger, CO2 aversion depends on a pathway that involves the mushroom body, a higher brain structure required for learning and memory in the fly. In objective 1, based on two prior behavioral screens, we will analyze the role of additional brain centers such as the lateral horn and the superior lateral protocerebrum in hunger-dependent processing of CO2 and the appetitive odor vinegar. In objective 2, we will dissect the neural underpinnings of polyamine perception. These molecules are indicators of protein breakdown that flies use in a mating state-dependent manner as cues for egg laying or foraging. Objective 3 will focus on the largely unexplored question of how infectious disease and subsequent immune reaction alters chemosensory choice behavior.Results of this proposal will establish a causal link between internal state-dependent chemosensory behavior and neural processing. Ultimately, understanding fundamental rules of context-dependent processing in the fly will provide an important framework for understanding human choice behavior. Dziedzina nauki natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesneurobiologycognitive neurosciencenatural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological scienceszoologyentomologynatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Słowa kluczowe Chemosensory processing Drosophila neural circuits neuromodulation innate behavior internal state context-dependent behavior Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-StG-2014 - ERC Starting Grant Zaproszenie do składania wniosków ERC-2014-STG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-STG - Starting Grant Instytucja przyjmująca TECHNISCHE UNIVERSITAET MUENCHEN Wkład UE netto € 1 115 199,90 Adres Arcisstrasse 21 80333 Muenchen Niemcy Zobacz na mapie Region Bayern Oberbayern München, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 115 199,90 Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko TECHNISCHE UNIVERSITAET MUENCHEN Niemcy Wkład UE netto € 1 115 199,90 Adres Arcisstrasse 21 80333 Muenchen Zobacz na mapie Region Bayern Oberbayern München, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 115 199,90 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Zakończenie uczestnictwa Niemcy Wkład UE netto € 382 400,10 Adres HOFGARTENSTRASSE 8 80539 Munchen Zobacz na mapie Region Bayern Oberbayern München, Kreisfreie Stadt Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 382 400,10