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High-resolution microscopy without lenses: a new generation of imaging technology

Project description

Revealing the future of lensless microscopes

The next generation of imaging technology is on the horizon, poised to revolutionise the field of visual sciences. Unlike conventional systems that rely on bulky optical components, this new approach uses a light source and an image sensor, resulting in a remarkably simplified and robust imaging system. The ERC-funded Lensless project will develop a smartphone-based lensless microscope for low-cost point-of-care diagnostics. This cutting-edge technology introduces a novel approach to imaging, enabling high-resolution imaging with exceptional contrast even in challenging scenarios. Its wide range of applications includes EUV metrology and soft-X-ray imaging, making previously unattainable tasks such as ultra-high-resolution surface profiling of lithographic wafers feasible.

Objective

Lensless imaging is an elegant approach to microscopy, in which a sharp image of an object is retrieved by numerical means rather than by actual optical components such as lenses. Such an approach allows high-resolution imaging using only a light source and an image sensor. Multi-wavelength phase retrieval (Witte et al., patent application PCT/NL2013/050618) provides a general framework for lensless imaging, which allows the development of surprisingly simple yet high-resolution imaging devices. By detecting wavelength-dependent differences in wave propagation, I have recently shown that amplitude and phase of an object field can be reconstructed with high contrast and resolution. This approach works for complex objects in both reflection and transmission. As such, lensless microscopes have advantages in size, cost, robustness and simplicity, and provide a powerful alternative to conventional imaging systems in many applications.
My aim with this proposal is to advance this new technology towards high-impact applications, and to forge a coordinated research program on lensless imaging technology and its applications. I will develop lensless microscopes to image many cell cultures in parallel, as well as smartphone-based lensless microscopes for low-cost point-of-care diagnostics in third-world countries. Lensless microscopy through optical fibers will be implemented as a novel tool for minimally invasive endoscopic imaging. Since the technology does not require precision optical components, I will be able to extend it to shorter wavelengths. Applications in EUV metrology and soft-X-ray imaging become feasible, such as ultra-high-resolution surface profiling of lithographic wafers.
This program provides exciting new prospects for fundamental science, industrial metrology and medical diagnostics alike. My expertise in lensless imaging and laser development provide me with an excellent starting point for the realization of such a new generation of imaging technology.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Host institution

STICHTING VU
Net EU contribution
€ 1 500 000,00
Address
DE BOELELAAN 1105
1081 HV Amsterdam
Netherlands

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Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 1 500 000,00

Beneficiaries (1)

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