Objectif Europe is facing a striking change in its demographics with an increasingly larger proportion of citizens aged 65 years and over. Aging is characterized by a progressive decline in the physiological functions of the body, with very notable effects on the heart. These effects are associated with a higher prevalence of arrhythmias, which, on top of deteriorating quality of life, increase the risk of other cardiovascular diseases like stroke, heart failure and neurological sequelae. Investigations targeting cardiac aging have often focused on assessing the effects of a specific contributing factor, at a single evaluation scale (molecular, cell, tissue, organ) and in many cases using animal species not relevant to humans in terms of aging mechanisms. MODELAGE proposes a multi-scale, multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels. MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans. Indices describing spatio-temporal dynamics of cardiac electrophysiology will be evaluated in a population of young to senescent individuals using a novel feedback control approach. Inter-individual age-related variations in those indices will be assessed and correlated with markers of biological age (as opposed to chronological age). By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment should be considered. Champ scientifique medical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-StG-2014 - ERC Starting Grant Appel à propositions ERC-2014-STG Voir d’autres projets de cet appel Régime de financement ERC-STG - Starting Grant Institution d’accueil UNIVERSIDAD DE ZARAGOZA Contribution nette de l'UE € 1 498 636,00 Adresse CALLE PEDRO CERBUNA 12 50009 Zaragoza Espagne Voir sur la carte Région Noreste Aragón Zaragoza Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 498 636,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSIDAD DE ZARAGOZA Espagne Contribution nette de l'UE € 1 498 636,00 Adresse CALLE PEDRO CERBUNA 12 50009 Zaragoza Voir sur la carte Région Noreste Aragón Zaragoza Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 498 636,00