Objectif The beginning of this century has seen the development of optical super-resolution fluorescence microscopic methods, which yield pictures to resolutions of a few tens of nanometers. This breakthrough has transformed the field of cellular biology, but relies on approaches generally demanding in terms of optics, and which can be applied only on limited classes of fluorophores. This project aims at preparing the commercialization of a new, simple, and cheap, way of extracting super-resolution from images obtained with classical confocal fluorescence microscopes. Currently, this approach yields images with a resolution between 80 nm to 50 nm, which can most likely be increased in a near future. This method can thus be used with any type of fluorophore, just by equipping (confocal) microscopes with a high-end X-Y table and a 2D detector. More complex super-resolution fluorescence microscopic techniques have generated more than 7000 citations in the last years, mostly in biology, but also in chemistry and material sciences. The proposed technology, which can i) easily be implemented for a limited cost and ii) requires no more maintenance and alignment than classical confocal microscopy, is expected to be rapidly implemented in a very large number of laboratories, thus generating new knowledge and a vast range of scientific advances. In the frame of this project, which is a direct consequence of the work started in the frame of the PhotProt ERC advanced grant (id n° 267333), we will in parallel i) improve the performances of this technology by modifying its present design, ii) perform the necessary patenting of this technology, iii) start market studies to evaluate its actual commercial potential iv) enter in contact with companies devoted to microscope engineering and development, and with detector manufacturers, to raise their interest, and envision under which form this new technology can be commercialized, how to conceive the corresponding commercial prototype. Champ scientifique natural sciencesphysical sciencesopticsmicroscopysuper resolution microscopynatural sciencesphysical sciencesopticsmicroscopyconfocal microscopy Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-PoC-2014 - ERC Proof of Concept Grant Appel à propositions ERC-2014-PoC Voir d’autres projets de cet appel Régime de financement ERC-POC - Proof of Concept Grant Institution d’accueil STICHTING VU Contribution nette de l'UE € 62 500,00 Adresse DE BOELELAAN 1105 1081 HV Amsterdam Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 62 500,00 Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire STICHTING VU Pays-Bas Contribution nette de l'UE € 62 500,00 Adresse DE BOELELAAN 1105 1081 HV Amsterdam Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 62 500,00 COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France Contribution nette de l'UE € 87 500,00 Adresse RUE LEBLANC 25 75015 PARIS 15 Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 87 500,00