Obiettivo Acute Respiratory Distress Syndrome (ARDS) is a devastating condition, which kills 40% of sufferers, resulting in hundreds of thousands of deaths worldwide annually. Despite decades of intensive research efforts, there are no clinical therapeutic strategies available for this catastrophic condition. In our ERC Starter Grant, HA-NFkB-VILI, we have shown Mesenchymal Stem Cells (MSCs) to be beneficial in several relevant preclinical ARDS models. However, for cell therapies to be successfully used in the clinic, they will need to be sourced allogeneically, culture passaged and cryofrozen for transport to the clinical site, where they can then thawed near the bedside and administered to the patient with ARDS.This project will therefore examine the potential of cryofrozen human MSCs, manufactured at the CCMI cell therapy facility at NUI Galway, in relevant models of ARDS.A demonstration that the cryofrozen CCMI-hMSC exhibit therapeutic potential would be a major step towards the clinical testing of these cells in patients with this devastating disease. Campo scientifico medical and health sciencesmedical biotechnologycells technologiesstem cells Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-PoC-2014 - ERC Proof of Concept Grant Invito a presentare proposte ERC-2014-PoC Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-POC - Proof of Concept Grant Istituzione ospitante UNIVERSITY OF GALWAY Contribution nette de l'UE € 149 101,00 Indirizzo UNIVERSITY ROAD H91 Galway Irlanda Mostra sulla mappa Regione Ireland Northern and Western West Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 149 101,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto UNIVERSITY OF GALWAY Irlanda Contribution nette de l'UE € 149 101,00 Indirizzo UNIVERSITY ROAD H91 Galway Mostra sulla mappa Regione Ireland Northern and Western West Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 149 101,00
