CRYDISProject ID: 644056
Driving innovation in pharmaceuticals: integrated studies of physical dissolution properties of crystalline and amorphous forms using enhanced orthogonal monitoring techniques
Gesamtkosten:EUR 216 000
EU-Beitrag:EUR 216 000
Aufruf zur Vorschlagseinreichung:H2020-MSCA-RISE-2014See other projects for this call
Finanzierungsprogramm:MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
The CRYDIS exchange programme will establish and support international and inter-sectoral transfer of knowledge and expertise in pharmaceutical and instrument science between several EU research institutes and industrial companies. It will also enhance understanding of the value of inter-sectoral exchange mechanisms for taking research to market.
CRYDIS undertakes innovative, collaborative research on the clinically-important topic of dissolution of drug substance particles in bio-relevant media and the undesired subsequent nucleation and re-precipitation of the drug prior to its absorption.
Using innovative advances in UV imaging technology, CRYDIS investigates the utility of novel dissolution assays as key tools to obtain fundamental data on the mechanism and kinetics of undesired nucleation and re-precipitation during or following dissolution, a significant problem for the pharmaceutical industry which struggles to obtain sufficient exposure to poorly soluble drug substances to ensure an effective dose is absorbed by the patient.
The key technologies in this proposal offer a step change in capability and functionality, offering the potential to undertake more detailed studies of the dissolution/re-precipitation processes relevant to pharmaceutical materials. Access to this key technology and the further development of its capability offers the potential for breakthroughs in development of process understanding and of robust and widely applicable protocols.
Additional value is brought to CRYDIS through close working with synergistic European networks, leveraging a greater knowledge input and impact outreach.
Running parallel with the science programme, an innovation management work-package analyses effectiveness of the exchange mechanism in building a shared culture, transferring knowledge and developing understanding of processes that drive a product to market. The outcomes of this will be used to advise and drive potential future exchange activities.
EU-Beitrag: EUR 130 500
EU-Beitrag: EUR 31 500
EU-Beitrag: EUR 9 000
Forest Row Business Park
RH18 5DW Forest Row
EU-Beitrag: EUR 27 000
CT13 9NG Sandwich, Kent
EU-Beitrag: EUR 18 000
YORK HOUSE OUTGANG LANE OSBALDWICK
YO19 5UP YORK