SAPHELYProject ID: 644242
Financé au titre de:
Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases
Détails concernant le projet
The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a focus in cancer. Disease identification will be based in the fast (<5 minutes), ultra-sensitive (sub-pM) and label-free detection of novel highly-specific microRNA (miRNA) biomarkers, using a small volume of whole blood (<100 μL). This POC analysis device, which will have a low cost (envisaged cost < €3000), will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates.
The ultra-high sensitivity required for the direct detection of miRNA biomarkers present in the bloodstream will be achieved by using a novel sensing amplification technique. This technique is based in the use of molecular beacon capture probes with an attached high index nanoparticle, so that the hybridization events are translated into the displacement of these nanoparticles from the sensor surface. The use of this self-amplification technique avoids the use of complex PCR-based amplification methods or labelling processes, which are difficult to implement on-chip.
The cost, size and weight reduction required for deploying an affordable handheld POC device will be achieved by using a novel power-based readout scheme for photonic bandgap sensing structures where the use of expensive, bulky and heavy tuneable lasers and spectrometers is avoided.
Special attention will be paid within the SAPHELY project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.
Contribution de l'UE: EUR 945 704
CAMINO DE VERA SN EDIFICIO 3A
Contribution de l'UE: EUR 323 513
NR4 7TJ NORWICH
Contribution de l'UE: EUR 344 915
FREDRIK BAJERS VEJ 5
Contribution de l'UE: EUR 443 750
STOCKHOLMER STRASSE 20
Contribution de l'UE: EUR 226 250
Contribution de l'UE: EUR 370 081
Vaestra Jaernvaegsgatan 4
745 39 ENKOEPING
Contribution de l'UE: EUR 207 750
DI ERICH THALLNER STRASSE 1
4782 ST FLORIAN AM INN
Contribution de l'UE: EUR 151 250
UNIT 16 HOLMESTONE ROAD
CT17 0UF DOVER
Contribution de l'UE: EUR 215 625
Beltrán Báguena 8