NanoPilotProject ID: 646142
A Pilot Plant for the Production of Polymer based Nanopharmaceuticals in Compliance with GMP
Total cost:EUR 6 283 988,75
EU contribution:EUR 6 283 988,75
Call for proposal:H2020-NMP-PILOTS-2014See other projects for this call
Funding scheme:RIA - Research and Innovation action
The aim of NanoPilot will be to set-up a flexible and adaptable pilot plant operating under GMP for the production of small batches of polymer-based nanopharmaceuticals, which exhibit significant potential in the field of drug-delivery particularly for the design of second-generation nanopharmaceuticals.
Three different processes will be established for the production of three different nanopharmaceuticals selected on the basis of their TRL and positive commercial evaluation: a) topical treatment of ocular pain associated with dry eye syndrome containing short interfering RNA and lactic acid, b) A resuspendable HIV nanovaccine for intranasal vaccination containing 12 peptides in its formulation. c) Hyaluronan based hollow spheres intended for intravesical instillation, for the treatment of interstitial cystitis/painful bladder syndrome.
State of the art production processes including micro reactors and highly advanced characterization techniques will ensure the quality of the nanodrugs. Existing laboratories suitable for large-scale production of biologics in compliance with GMP, and owned by the coordinator, will be adapted and certified within this project to enable the operability of the pilot plant.
NanoPilot consists of nine complementary partners composed by 1 Industry and 2 academia developers of the nanosystems to scale-up. A research Institute expert in nanoparticle characterizacion and already operating in compliance with Good laboratory practices. An SME and an Industry that will develop ad-hoc continuous flow reactors for the optimization of two of the three processes. A consultancy (SME) expert in Quality system implementation and laboratory information management systems. A second consultancy (SME) in charge of the business plan, that will also help the coordinator in dissemination and exploitation activities. Finally, a research centre with a recorded track in nanomedicine, already operating under ISO 9001, and will be in charge of the pilot plant.
EU contribution: EUR 2 045 560
PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON
20009 SAN SEBASTIAN
EU contribution: EUR 531 500
EU contribution: EUR 273 500
COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
15782 SANTIAGO DE COMPOSTELA
EU contribution: EUR 643 118,75
PLAZA DESCUBRIDOR DIEGO DE ORDAS 3
EU contribution: EUR 84 973,21
KONRAD ADENAUER ALLEE 11
EU contribution: EUR 586 450
6167 RD GELEEN
EU contribution: EUR 981 662,50
CALLE AGUSTIN QUEROL 8
EU contribution: EUR 198 441,25
EU contribution: EUR 670 750
AVENUE DU DOCTEUR ALBERT SCHWEITZER - CENTRE CONDORCET 162
EU contribution: EUR 268 033,04