Objective
Europe’s pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Györgyi even described life itself as “water dancing on the tune of solids”. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry will complement his current research profile and allow him to embark at the highest scientific level in a for society very important research area.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.