Cel Today insulin resistance (IR) is reaching pandemic proportions and it is predicted to emerge a leading worldwide morbidity by 2030. Immune cells, including the so-called adipose tissue macrophages (ATMs) have key roles in the development of this disease. Pharmacological intervention to shape ATM differentiation and function may be a straightforward approach to prevent or combat IR. However the stem cell origin of ATMs is still unclear, which blocks the development of such prevention or treatment strategies. Recent reports show that some specific sets of macrophages develop from embryonic hematopoietic stem cells (eHSCs) and not from the bone marrow as it was postulated before. Our preliminary studies raise the possibility that eHSCs are present in the mouse and the human adipose tissue and these stem cells replenish the ATMs in adulthood. The major scientific objectives of this project are to (a) address the critical question whether ATMs are derived from eHSCs, and (b) define whether the eHSC-derived ATMs can cause IR. These are novel and non-conventional ideas on the determination of IR and are challenging the current wisdom on ATM origin. The deliverables of this project may open a new path to alleviate or prevent IR through eHSCs. Dziedzina nauki medical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health scienceshealth sciencesnutritionobesity Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator UNIVERSITAET ULM Wkład UE netto € 159 460,80 Adres Helmholtzstrasse 16 89081 Ulm Niemcy Zobacz na mapie Region Baden-Württemberg Tübingen Ulm, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 159 460,80