Objective
Insects are gaining resistance to commercially available pesticides and effective insecticides (e.g. neonicotinoids) are currently being banned. Consequently, there is a real threat that the EU vegetable production will be affected. Wild tomato species have the ability to defend themselves by producing natural defence compounds that have a toxic or repellent effect on insects. These compounds are produced and stored in glandular hairs (trichomes) on the plant stem and leaf surface. Extensive breeding in protected environments led to the loss of these defence compounds in cultivated tomatoes. It was previously shown that the introduction of the terpene 7-epizingiberene biosynthetic pathway from a wild tomato in trichomes of cultivated tomato results in an enhanced resistance to insects. However, the regulatory factors that govern the production of these defence compounds seem also essential for successful incorporation of ‘wild resistance’ into breeding material. Here, I aim to discover metabolic defence mechanisms present in the trichomes of wild tomato species that can be re-introduced into cultivated tomato with a focus on post-transcriptional regulation of biosynthetic pathways. I will evaluate insect resistance in a collection of wild and cultivated tomato accessions and associate phenotypic and transcriptional data via a Systems Biology approach. I will also sequence small RNAs and compare them quantitatively with messenger RNAs to identify post-transcriptional regulations. Next, I will follow a comparative genomic approach by mapping the selected transcripts to their corresponding tomato genomes to associate polymorphisms and resistance phenotypes. These results will be directly translated into molecular markers that the industry can implement in breeding programmes. This proposal will help me become an independent researcher, combining my background in plant biology with knowledge on bioinformatics, biostatistics and state-of-the-art technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science data mining
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1012WX Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.