Objective
Plant (+)strand RNA viruses account for important losses in crop yields worldwide. They complete complex infectious cycles by replicating, moving and inactivating plant defense mechanisms through multiple interactions of their RNA or proteins with host factors. Plants have evolved two main antiviral immunity systems operated by ARGONAUTE (AGO) proteins that target viral RNAs in the RNA silencing pathway or by resistance proteins that recognize viral-encoded proteins through protein-protein interactions. However, neither the identification of AGO target sites in viral RNAs nor the elucidation of the entire repertoire of proteins interacting with viral proteins has been reported for any plant virus. Now, the recent development of new technologies (and associated tools) such as high-throughput DNA sequencing and high performance mass spectrometry (MS) platforms makes possible to address these questions at a genome-wide level. InterAcTEV will combine these new technologies to study the recently described Arabidopsis/Tobacco etch virus (TEV)-TAMPS pathosystem with a multidisciplinary approach aimed to identify AGO target sites in TEV RNAs and to generate the first complete protein-protein interactome map for a plant virus. First, RNA-immunoprecipitation coupled with high-throughput sequencing methods will be optimized to identify AGO target sites in TEV RNAs at a genome-wide level. Second, we will combine novel high-affinity purification methods with MS analyses to identify the specific pool of Arabidopsis proteins interacting with each TEV protein. InterAcTEV will generate key knowledge to open new avenues for the understanding of resistance mechanisms in plants and to develop novel antiviral strategies for crop protection and securement of world’s food supply. Finally, the funding of InterAcTEV will allow the Experienced Researcher to initiate his own research project in the host laboratory and facilitate his transition to an independent research position in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.