Cel In Europe, infections caused by multidrug-resistant bacteria lead to more than 25,000 deaths and expenses of billions of euros per year. These numbers dramatically increase when the rest of the world is taken into consideration. Shockingly, the pace of production of new antibiotics to control such microorganisms is stagnating. Therefore, developing new synthetic tools that enable the synthesis of scaffolds with potential antibiotic properties is crucial. Metal catalysed C–H activation represents a versatile tool for building chemical complexity. It mostly relies on directing functional groups to functionalize C–H bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new C–H activation mode that enables the conversion of hindered amines into β-lactams. The first aim of this project is to develop this new reactivity mode into a versatile transformation that is able to convert a variety of cyclic and acyclic amines into substituted β-lactam scaffolds. To accomplish this goal, a multi parallel platform based on mass spectrometry, relying either on standard high-throughput procedures or flow chemistry, will be implemented and used to screen a large number of conditions to expand the scope of this new pathway for β-lactams. The flow chemistry system for reaction evaluation will be design in collaboration with Professors Alexei Lapkin (Dept. Chemical Engineering and Biotechnology) and Steve Ley (Chemistry Dept.) from the University of Cambridge. The readily discovered new conditions for C–H activation will then be employed to synthesize a plethora of β-lactams and β-sultam analogs starting from simple secondary amines. Finally, in collaboration with Professor David Spring (Chemistry Dept. University of Cambridge), the bioactivity of the resulting scaffolds will be evaluated against multidrug-resistant bacteria. Dziedzina nauki natural scienceschemical sciencesorganic chemistryorganic acidsnatural sciencesbiological sciencesmicrobiologybacteriologynatural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencesorganic chemistryalcoholsnatural scienceschemical sciencesorganic chemistryamines Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Wkład UE netto € 183 454,80 Adres TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Zjednoczone Królestwo Zobacz na mapie Region East of England East Anglia Cambridgeshire CC Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 183 454,80
