Cel The overall goal of this project is to provide a theoretical context encompassing motivation, motor control theory and motor decision-making. How does the brain relate incentive motivation to motor behaviour? How are these principles altered under Parkinson’s disease (PD)? The fact that three of PD’s major motor symptoms: bradykinesia, akinesia and hypokinesia are consistent with a lesser than normal motor invigoration, emphasizes the relationship between motivation and movement, strongly suggesting that PD may be reviewed as a disorder of motivation. This project is concerned with the two major quandaries impending to systematically test this hypothesis: the absence of a normative context relating motivation to motor control theory and the lack of an independent scale of incentive motivation. Therefore, we propose a novel unifying model called Quantitative Motor Control for Decision-Making (QTMODEM) to characterize motor processes as a function of incentive motivation for different kinds of movements. In other words, the QTMODEM intends to formalise the relationship between the selection of motor parameters and an independent metric of motivation derived from electro-encephalography. We will first quantify this relationship with a series of psychophysics experiments with healthy participants by varying two factors: the nature of their movements and the participants’ level of incentive motivation. Second, we will perform experiments with PD patients to gain a quantitative insight into their dysfunctional relationship between motivation and movement statistics. Third, we will build the QTMODEM based on the dynamics of a trade-off between motivation and motor costs, and optimal feedback control theory. Unlike previous models, we predict that the incorporation of motivation into the QTMODEM, will provide the proper normative context for the characterization of the dynamics between motivation and the selection of motor parameters, both under normal and PD conditions. Dziedzina nauki natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologyparkinson Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator UNIVERSIDAD POMPEU FABRA Wkład UE netto € 158 121,60 Adres PLACA DE LA MERCE, 10-12 08002 Barcelona Hiszpania Zobacz na mapie Region Este Cataluña Barcelona Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 158 121,60
